Anthracycline Antibiotics. New Analogues, Methods of Delivery, and Mechanisms of Action

Content: Unresolved structure-activity relationships in anthracycline analogue development / Edward M. Acton — Non-cross-resistant anthracyclines with reduced basicity and increased stability of the glycosidic bond / Waldemar Priebe, Piotr Skibicki, Oscar Varela, Nouri Neamati, Marcos Sznaidman, Krzysztof Dziewiszek, Grzegorz Grynkiewicz, Derek Horton, Yiyu Zou, Yi-He Ling, and Roman Perez-Soler — Fluorinated anthracyclinones and their glycosylated products / Antonio Guidi, Franca Canfarini, Alessandro Giolitti, Franco Pasqui, Vittorio Pestellini, and Federico Arcamone — Semisynthetic rhodomycins and anthracycline prodrugs / Cenek Kolar, Klaus Bosslet, Jörg Czech, Manfred Gerken, Peter Hermentin, Dieter Hoffmann, and Hans-Harold Sedlacek — Synthetic options for reversal of anthracycline resistance and cardiotoxicity / Claude Monneret, Jean-Claude Florent, Jean-Pierre Gesson, Jean-Claude Jacquesy, François Tillequin, and Michel Koch — Synthesis and biological activities of fluorinated daunorubicin and doxorubicin analogues / Tsutomu Tsuchiya and Yasushi Takagi — Redox chemistry of anthracyclines and use of oxomorpholinyl radicals / Tad H. Koch and Giorgio Gaudiano — Synthesis of anthraquinone analogues of linked anthracycline / Ping Ge and Richard A. Russell — Synthesis and study of structure-activity relationships of new classes of anthracyclines / Antonino Suarato, Francesco Angelucci, Alberto Bargiotti, Michele Caruso, Daniela Faiardi, Laura Capolongo, Cristina Geroni, Marina Ripamonti, and Maria Grandi — Molecular recognition of DNA by daunorubicin / Jonathan B. Chaires — Adducts of DNA and anthracycline antibiotics : structures, interactions, and activities / Jasmine Y.-T. Wang, Mark Chao, and Andrew H.-J. Wang — DNA topoisomerases and their inhibition by anthracyclines / Yves Pommier — Anthracycline antihelicase action : new mechanism with implications for guanosine-cytidine intercalation specificity / Nicholas R. Bachur, Robin Johnson, Fang Yu, Robert Hickey, and Linda Malkas — Membrane biophysical parameters influencing anthracycline action / Ratna Mehta and Thomas G. Burke — Signal transduction systems in doxorubicin hydrochloride mechanism of action / Paul Vichi, James Song, Jean Hess, and Thomas R. Tritton — Analysis of multidrug transporter in living cells : application to uptake and release of anthracycline derivatives by drug-resistant K562 cells / Arlette Garnier-Suillerot, Frédéric Frézard, Marie-Nicole Borrel, Elene Pereira, Jolanta Tarasiuk, and Marina Fiallo — Role of reactive-oxygen metabolism in cardiac toxicity of anthracycline antibiotics / James H. Doroshow — Amelioration of anthracycline-induced cardiotoxicity by organic chemicals / Donald T. Witiak and Eugene H. Herman — Use of drug carriers to ameliorate the therapeutic index of anthracycline antibiotics / Roman Perez-Soler, Steven Sugarman, Yiyu Zou, and Waldemar Priebe.